Cyclic AMP: common pathway for different drugs.

The cyclic AMP pathway.

Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first second messenger to be identified and plays fundamental roles in cellular responses to many hormones and neurotransmitters (Sutherland and Rall 1958). The intracellular levels of cAMP are regulated by the balance between the activities of two enzymes (see Fig. 1): adenylyl cyclase (AC) and cyclic nucleotide phosphodiesterase (PDE). Diffe...

Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches☆

Escherichia coli cyclic-AMP receptor protein (CRP) represents one of the paradigms of bacterial gene regulation. Yet despite decades of intensive study, new information continues to emerge that prompts reassessment of this classic regulatory system. Moreover, in recent years CRPs from several other bacterial species have been characterized, allowing the general applicability of the CRP paradigm...

آدنوزین منوفسفات حلقوی ( Cyclic AMP )

Effects of various drugs on myocardial cyclic AMP.

Effects of norepinephrine, J3-adrenergic blocking agents, theophylline ethylenediamine (TEDA) and digoxin on myocardial cyclic AMP concentration and those of various vasodilators both on myocardial cyclic AMP in vivo and phosphodiesterase (PDE) activity in vitro were investigated by radioimmunoassay of cyclic AMP. The mean concentration of myocardial cyclic AMP was 0.318 p mole/mg in the left v...

cyclic amp pathway modifies memory through neural cell adhesion molecule alterations in the rat hippocampus.

neural cell adhesion molecules (ncams) are known to influence memory by affecting neural cell-cell and cell-extracellular matrix junctions. this study investigated the possible role of camp pathway in the expression of hippocampal ncam and its polysialylated derivative (psa-ncam). the following pharmacological tools were employed for manipulation of camp pathway: a) forskolin; the activator of ...